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November 14, 2025AntibioticsOpen Access

Multicentric Surveillance of Antimicrobial Resistance to Generate Data-Driven Regional Antibiograms: A Laboratory-Based Cross-Sectional Study in Pakistan

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Authors

NNNadia NoreenAAAdeel AslamMAMateen Abbas

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Overview

Cross-sectional study identifies high antimicrobial resistance in bacteria from infections, suggesting urgent need for local treatment guidelines.

Key Points

  • The aim was to conduct surveillance of antimicrobial resistance to create regional antibiograms for informed therapy in Pakistan.
  • Multicentric surveillance across three tertiary hospitals in Northern Punjab, Pakistan.
  • Retrospective cross-sectional study collecting data from 485 patients with bacterial infections.
  • Antimicrobial susceptibility testing conducted using CLSI guidelines.
  • 60.0% of infections were caused by Gram-positive bacteria, primarily Staphylococcus aureus (12.2%).
  • 40.0% of infections were caused by Gram-negative bacteria, mainly Escherichia coli (14.0%) and Pseudomonas aeruginosa (5.8%).
  • 25.0% of S. aureus isolates were methicillin-resistant (MRSA), and ~30% of E. coli were resistant to third-generation cephalosporins.

Cite This Study

Noreen et al. (2025) studied this question.

synapsesocial.com/papers/692519a2c0ce034ddc353e4ehttps://doi.org/10.3390/antibiotics14111154
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Antimicrobial Resistance (AMR) patterns among patients admitted in Tertiary Care Hospital of South Punjab, Pakistan2025
  2. 2Ten-year trends in sepsis-causing multidrug-resistant pathogens: a nationwide multi-center laboratory-based surveillance in Pakistan (2013–2022) and predictive forecasting of antimicrobial resistance (2030)2026
  3. 3Antibiotic Resistance Pattern of Pathogens, Among Intensive Care Unit Patients: A Cross-Sectional Study at a Tertiary Care Hospital in Karachi, Pakistan2026
  4. 4Antimicrobial Resistance, Pathogen Transmission and Cross-Infections across Regions and Borders2024
  5. 5The antibiogram of pus cultures in federal tertiary care hospital, Islamabad and its utility in antimicrobial stewardship2024 · 6 citations