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November 14, 2025BMC CancerOpen Access

Characteristics of extracellular vesicle-derived lncRNAs during the progression of HBV-related hepatocellular carcinoma

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Authors

YMYanan MaCLCheng LouJLJing Liang

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Overview

This study identifies lncRNA biomarkers in extracellular vesicles, revealing roles in cell proliferation and liquid biopsy potential for HCC detection.

Key Points

  • The aim is to characterize extracellular vesicle-derived lncRNAs during liver disease progression, particularly in hepatocellular carcinoma.
  • Isolated serum extracellular vesicles from 24 participants through ultracentrifugation.
  • Utilized transmission electron microscopy, nanoparticle tracking analysis, and Western blot for validation.
  • Conducted high-throughput transcriptome sequencing for RNA expression analysis.
  • Performed functional enrichment and PPI network analysis to explore biological roles of lncRNAs.
  • Identified 133 differentially expressed lncRNAs in HCC patients.
  • Revealed 10 core lncRNAs linked to HCC progression.
  • Showed involvement of lncRNAs in cell proliferation regulation and ion transport.
  • Constructed a lncRNA-miRNA-mRNA regulatory network with 62 nodes and 68 edges.

Cite This Study

Ma et al. (2025) studied this question.

synapsesocial.com/papers/692519a7c0ce034ddc353f5dhttps://doi.org/10.1186/s12885-025-15237-y
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