Observational study reveals no significant improvement in left atrial function in heart failure patients using SGLT2 inhibitors, suggesting diastolic dysfunction plays a larger role.
SGLT2 inhibitor use was not associated with significant improvement in LA volume or functional parameters in patients with HF and reduced or mildly reduced EF. The prognostic value of LA functions appears to be primarily influenced by diastolic dysfunction and ventricular remodeling rather than SGLT2 inhibitor therapy.
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Duman et al. (2025) studied this question.
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