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November 14, 2025Renal FailureOpen Access

Association between estimated plasma volume status and risk of sepsis-associated acute kidney Injury: a retrospective cohort study using the MIMIC-IV database

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Authors

YCYifeng ChenMYMingkun YangYLYanwen Lu

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Overview

Retrospective cohort analysis reveals logistic regression links higher plasma volume to increased mortality in patients, suggesting improved fluid management strategies.

Key Points

  • This research investigates the association between estimated plasma volume status and outcomes in patients with sepsis-associated acute kidney injury.
  • Retrospective cohort study utilizing data from the MIMIC-IV database
  • Analysis included 15,789 patients with sepsis-associated acute kidney injury
  • Used Cox regression and Kaplan-Meier analysis for mortality evaluation
  • Logistic regression assessed renal recovery
  • Restricted cubic spline model explored nonlinear relationships between ePVS and mortality.
  • The 28-day mortality rate for patients with SA-AKI was 23.2%
  • Higher estimated plasma volume status correlated with increased 28-day mortality (HR = 1.05)
  • Elevated plasma volume was linked to reduced renal recovery (OR = 0.96)
  • RCS indicated a nonlinear relationship, identifying an inflection point at 5.47 dL/g
  • High-ePVS group showed significantly higher long-term mortality and lower renal recovery compared to low-ePVS group.

Cite This Study

Chen et al. (2025) studied this question.

synapsesocial.com/papers/692519acc0ce034ddc35417ehttps://doi.org/10.1080/0886022x.2025.2586382
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