November 8, 2021BMC Cardiovascular DisordersOpen Access

Estimated plasma volume status (ePVS) is a predictor for acute myocardial infarction in-hospital mortality: analysis based on MIMIC-III database

Q: What are the key findings of this study?

High estimated plasma volume status (ePVS ≥ 5.28 mL/g) at admission was significantly associated with increased in-hospital mortality in patients with acute myocardial infarction (OR 1.09).

Q: What is the clinical evidence from this study?

Study design: Observational. Population: Acute myocardial infarction (AMI) (n=1534). Intervention: High estimated plasma volume status (ePVS ≥ 5.28 mL/g) vs. Low estimated plasma volume status (ePVS < 5.28 mL/g). Primary outcome: In-hospital mortality (OR 1.09, 95% CI 1.06-1.12, p=<0.001).

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Why the study?

Estimated plasma volume status correlates with poor prognosis in heart failure, but its association with outcomes in acute myocardial infarction had not been investigated.

Does high estimated plasma volume status (ePVS) predict increased in-hospital mortality in patients with acute myocardial infarction?

Population

1534 AMI patients from the MIMIC-III database

Comparison

High-ePVS (≥ 5.28 mL/g) vs low-ePVS (< 5.28 mL/g)

Design

Retrospective database study

Key result

High estimated plasma volume status (ePVS ≥ 5.28 mL/g) at admission was significantly associated with increased in-hospital mortality in patients with acute myocardial infarction (OR 1.09).

Authors

JCJun Chen JSJiayi Shen DCDongsheng Cai

Discussion

Member takes

Overview

Suggests admission plasma volume may serve as a prognostic marker in acute MI; leaves open whether.

Study Design

Type

Observational (n=1,534)

Multicenter

Structured PICO

Does high estimated plasma volume status (ePVS) predict increased in-hospital mortality in patients with acute myocardial infarction?

Population

1,534 adult patients with acute myocardial infarction from the MIMIC-III database, evaluated for the association between estimated plasma volume status and in-hospital mortality.

Exposure

High estimated plasma volume status (ePVS ≥ 5.28 mL/g) calculated at hospital admission using Duarte's formula (based on hemoglobin and hematocrit).

Comparator

Low estimated plasma volume status (ePVS < 5.28 mL/g).

Outcome

In-hospital mortality (defined as survival status at hospital discharge).hard clinical

Main Result

Odds Ratio: 1.09 (95% CI 1.06–1.12)

Absolute Event Rate: 11.73% vs 3.13%

p-value: p=<0.001

Higher estimated plasma volume status (ePVS ≥ 5.28 mL/g), easily calculated from routine hemoglobin and hematocrit, is an independent predictor of in-hospital mortality in patients with acute myocardial infarction.

Limitations

Observational study design with limited sample size
ePVS derived only from the first laboratory test on admission, not accounting for in-hospital trends
Several potential confounding variables (albumin, BNP) were missing and unable to be assessed
Did not subdivide AMI into STEMI or NSTEMI
Unclear if the specific target ePVS goal of 5.28 mL/g applies to different subgroups

Cite This Study

Chen et al. (2021) conducted an observational in Acute myocardial infarction (AMI) (n=1,534). High estimated plasma volume status (ePVS ≥ 5.28 mL/g) vs. Low estimated plasma volume status (ePVS < 5.28 mL/g) was evaluated on In-hospital mortality (OR 1.09, 95% CI 1.06-1.12, p=<0.001). High estimated plasma volume status (ePVS ≥ 5.28 mL/g) at admission was significantly associated with increased in-hospital mortality in patients with acute myocardial infarction (OR 1.09).

synapsesocial.com/papers/6a8d699a50db337a287dcc8a https://doi.org/10.1186/s12872-021-02338-2

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November 8, 2021BMC Cardiovascular DisordersOpen Access

Estimated plasma volume status (ePVS) is a predictor for acute myocardial infarction in-hospital mortality: analysis based on MIMIC-III database

View Full Paper

Ask AI

Bookmark

Why the study?

Estimated plasma volume status correlates with poor prognosis in heart failure, but its association with outcomes in acute myocardial infarction had not been investigated.

Does high estimated plasma volume status (ePVS) predict increased in-hospital mortality in patients with acute myocardial infarction?

Population

1534 AMI patients from the MIMIC-III database

Comparison

High-ePVS (≥ 5.28 mL/g) vs low-ePVS (< 5.28 mL/g)

Design

Retrospective database study

Key result

High estimated plasma volume status (ePVS ≥ 5.28 mL/g) at admission was significantly associated with increased in-hospital mortality in patients with acute myocardial infarction (OR 1.09).

Authors

JCJun Chen JSJiayi Shen DCDongsheng Cai

Discussion

Member takes

Overview

Suggests admission plasma volume may serve as a prognostic marker in acute MI; leaves open whether.

Study Design

Type

Observational (n=1,534)

Multicenter

Structured PICO

Does high estimated plasma volume status (ePVS) predict increased in-hospital mortality in patients with acute myocardial infarction?

Population

1,534 adult patients with acute myocardial infarction from the MIMIC-III database, evaluated for the association between estimated plasma volume status and in-hospital mortality.

Exposure

High estimated plasma volume status (ePVS ≥ 5.28 mL/g) calculated at hospital admission using Duarte's formula (based on hemoglobin and hematocrit).

Comparator

Low estimated plasma volume status (ePVS < 5.28 mL/g).

Outcome

In-hospital mortality (defined as survival status at hospital discharge).hard clinical

Main Result

Odds Ratio: 1.09 (95% CI 1.06–1.12)

Absolute Event Rate: 11.73% vs 3.13%

p-value: p=<0.001

Limitations

Observational study design with limited sample size
ePVS derived only from the first laboratory test on admission, not accounting for in-hospital trends
Several potential confounding variables (albumin, BNP) were missing and unable to be assessed
Did not subdivide AMI into STEMI or NSTEMI
Unclear if the specific target ePVS goal of 5.28 mL/g applies to different subgroups

Cite This Study

synapsesocial.com/papers/6a8d699a50db337a287dcc8a https://doi.org/10.1186/s12872-021-02338-2

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