Key result
Elevated estimated plasma volume status predicts mortality and rehospitalization in heart failure patients.
Why the study?
Despite treatment advances, prognosis improvements in heart failure remain limited, and non-invasive estimation of plasma volume status may enhance prognostic accuracy and management.
Does elevated estimated plasma volume status predict adverse outcomes including mortality and rehospitalization in patients with heart failure?
Meta-Analysis
Does elevated estimated plasma volume status predict adverse outcomes including mortality and rehospitalization in patients with heart failure?
Non-invasive estimation of plasma volume status using hemoglobin and hematocrit may serve as a useful prognostic marker for mortality and rehospitalization in heart failure patients.
Supports ePVS for HF risk stratification; reinforces its prognostic value across studies.
Background: Heart failure (HF) remains a leading cause of global mortality; however, despite treatment advances, improvements in prognosis are limited. Non-invasive estimation of plasma volume status (ePVS) from hemoglobin and hematocrit may enhance prognostic accuracy and management. This meta-analysis investigates the association of ePVS with adverse outcomes in HF patients. Methods: We searched PubMed, Embase, Cochrane, and Web of Science up to June 8, 2024, using specific keywords. Two independent researchers performed the literature search and data extraction, resolving discrepancies through discussion or a third researcher if necessary. Hazard ratios (HRs) and 95% confidence intervals (CIs) were extracted and synthesized using a random-effects model. Sensitivity and subgroup analyses were conducted to explore heterogeneity. Results: = 43%). Sensitivity analysis confirmed result stability, and subgroup analysis showed persistent heterogeneity. Conclusions: Elevated ePVS predicts HF mortality and rehospitalization. Prospective validation of ePVS is warranted to assess its potential utility for improving risk stratification in clinical practice.
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Wang et al. (2026) conducted a meta-analysis in Heart failure. Elevated estimated plasma volume status (ePVS) was evaluated on Heart failure mortality and rehospitalization. Elevated estimated plasma volume status (ePVS) predicts heart failure mortality and rehospitalization.
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