Prognostic Implications of Plasma Volume Status Estimates in Heart Failure With Preserved Ejection Fraction: Insights From TOPCAT
Why the study?
Prior studies of plasma volume expansion either excluded or had limited representation of patients with HFpEF, leaving its prognostic relationship in HFpEF unclear.
Is calculated plasma volume status associated with adverse clinical outcomes in patients with HFpEF?
Population
3414 TOPCAT enrollees with HFpEF and available haematocrit and weight data
Comparison
Higher vs lower calculated plasma volume status
Design
Post hoc analysis of a clinical trial cohort
Authors
Discussion
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Member takes
Implication
May inform HFpEF risk stratification; hypothesis-generating for plasma volume-targeted trials.
Structured PICO
Is calculated plasma volume status associated with adverse clinical outcomes in patients with HFpEF?
P
Population
3,414 patients with heart failure with preserved ejection fraction (HFpEF) enrolled in the TOPCAT trial with available haematocrit and weight data.
I
Intervention
Calculated plasma volume status (PVS) derived from the Hakim formula
O
Outcome
Primary composite endpoint, all-cause death, heart failure hospitalization, and cardiovascular deathcomposite
Higher calculated estimates of plasma volume status are independently associated with a higher risk of long-term clinical outcomes, particularly heart failure hospitalization, in patients with HFpEF.
Cite This Study
Grodin et al. (2019) studied this question.