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This research evaluates the immune response in rabbits to mRNA-based immunogens targeting HIV-1.

November 14, 2025VaccinesOpen Access

Evaluating the Immune Response in Rabbits to an Escalating Dose of mRNA-Based HIV-1 Env Immunogens

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This research evaluates the immune response in rabbits to mRNA-based immunogens targeting HIV-1.
Rabbits received escalating doses of mRNA-LNP immunogens with protein boosts.
Antibody responses were assessed through binding and neutralization tests.
Comparison was made between escalating dose immunization and standard bolus immunization.
Both groups developed strong homologous anti-Env antibody responses.
No significant difference in antibody binding between groups was observed.
A higher neutralization titer against HIV-1AD8 was noted in the escalating dose group.

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Immunogen design shows potential for enhancing antibody responses in rabbits, indicating vaccination strategies may need refinement.

Ahmed et al. (2025) studied this question.

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