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The aim is to evaluate the antibody response to an HIV V1V2 mRNA-LNP vaccine and its potential to enhance vaccine efficacy.

An HIV V1V2 mRNA-LNP vaccine induces strong, cross-clade functional antibody responses in mice and rhesus macaques 2307530

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The aim is to evaluate the antibody response to an HIV V1V2 mRNA-LNP vaccine and its potential to enhance vaccine efficacy.
Immunogenicity assessed in mice, rabbits, and rhesus macaques after multiple immunizations.
Quantified responses using Luminex assays, virion and cell-surface Env recognition assays, and Fc receptor binding.
Evaluated antibody-dependent cellular phagocytosis (ADCP) to gauge functional attributes.
In mice, two doses elicited robust, cross-reactive serum IgG responses recognizing Env structures.
Rabbits displayed minimal V1V2-specific responses despite four vaccinations; responses focused on the scaffold.
Rhesus macaques developed comparable high-level V1V2-specific antibody responses after two vaccinations.

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Randomized trial examines antibody responses to an mRNA vaccine in mice and macaques, indicating strong immunogenicity.

Hioe et al. (2026) studied this question.

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