Post hoc analysis evaluates neoadjuvant chemotherapy with radiation in pancreatic cancer, suggesting improved survival and reduced recurrence.
Although this study was a retrospective post hoc analysis of 2 phase II trials, which represents a major limitation, neoadjuvant chemotherapy with concurrent radiotherapy possibly improve survival compared with chemotherapy alone by suppressing local recurrence through a powerful local antitumor effect of radiation.
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Akita et al. (2025) studied this question.
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