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November 14, 2025GenesOpen Access

Molecular Characterization and Functional Effect on Canine Peripheral Blood Mononuclear Cells of an Uncharacterized Major Egg Antigen EGR-01664 from Echinococcus granulosus

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Authors

JHJuncheng HuangBXBo XinwenXCXuke Chen

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Overview

Molecular characterization reveals EGR-01664 modulates immune responses in canine PBMCs, suggesting its role in immunity and parasitism.

Key Points

  • To analyze the molecular properties and immune functions of the EGR-01664 antigen from Echinococcus granulosus.
  • Investigated the EGR-01664 gene and expressed recombinant protein
  • Analyzed gene transcription through quantitative PCR
  • Conducted immunofluorescence assays to study localization
  • Assessed immunomodulatory effects of rEGR-01664 on canine PBMCs
  • rEGR-01664 was recognized by sera from infected dogs
  • mRNA levels were higher in protoscoleces compared to adults (p < 0.0001)
  • 20 μg/mL of rEGR-01664 activated IL-10, TGF-β1, IL-17A, and Bax expression
  • Higher concentrations inhibited IFN-γ, Bcl-2, GSDMD, IL-18, and IL-1β expression
  • EGR-01664 likely plays a role in parasitic immune evasion and regulation.

Cite This Study

Huang et al. (2025) studied this question.

synapsesocial.com/papers/692519acc0ce034ddc354314https://doi.org/10.3390/genes16111384
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  1. 1Molecular characterization of Echinococcus granulosus EGR-02244 and its functional role in canine peripheral blood mononuclear cells2026
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