Association of Serial Ventricular Routine Cerebrospinal Fluid Findings with Complications and Outcome in Aneurysmal Subarachnoid Hemorrhage: A Retrospective Observational Study
Retrospective study shows cerebrospinal fluid parameters associate with outcomes in aneurysmal subarachnoid hemorrhage, indicating potential clinical implications.
Key Points
This study aims to explore the relationship between cerebrospinal fluid parameters and clinical outcomes in patients with aneurysmal subarachnoid hemorrhage.
Retrospective observational study with 702 cerebrospinal fluid samples from 169 patients with aSAH.
Analysis of routine cerebrospinal fluid parameters including leukocyte count, erythrocyte count, CSF lactate, and CSF/plasma glucose ratio.
Utilization of generalized linear mixed-effects modeling for analyzing longitudinal dynamics of cerebrospinal fluid parameters.
Cerebrospinal fluid leukocyte count peaked around day 4 to 8 post-aSAH and correlated with delayed cerebral ischemia.
Higher initial erythrocyte count with a rapid decline indicated a favorable functional outcome.
Persistently elevated CSF lactate levels were linked to unfavorable outcomes.