Copper-catalyzed amination improves functionalization of amino acid Schiff bases, suggesting new synthetic pathways.
We have developed a catalytic β-C-H amination of amino acid derivatives using amino acid Schiff bases, which are traditionally employed only in α-functionalization reactions. The present transformation expands the synthetic utility of these widely available building blocks by enabling intermolecular β-C-H amination. Detailed mechanistic studies revealed that the copper catalyst operates via a dual catalytic mode that is essential for the success of the reaction.
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Ochiishi et al. (2025) studied this question.
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