Design, synthesis, in silico studies, molecular docking, ADMET and anticancer activity of novel N -substituted-4-pyrazole derivatives

Hager G. El-kasabi; Margret M. Girges; Ahmed F. El-Sayed; Ghada E. Abdel‐Ghani

doi:10.1080/17568919.2025.2575750

November 14, 2025Future Medicinal Chemistry

Design, synthesis, in silico studies, molecular docking, ADMET and anticancer activity of novel N -substituted-4-pyrazole derivatives

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Key Points

Anticancer activity improved in pyrazole derivatives with electron-withdrawing groups, and specific combinations show enhanced effects.
Key evidence indicates that synthesized compounds demonstrate significant efficacy in cancer inhibition through targeted molecular interactions.
Analysis of molecular docking provided insights into the interactions between thiazole and various pyrazole derivatives to enhance biological activity.
Findings may enable the development of new cancer therapies based on effective pyrazole derivative combinations for better treatment outcomes.

Implication

Synthesis and molecular docking reveal improved anticancer activity in pyrazole derivatives, suggesting potential therapeutic use.

Abstract

The activity of synthesized 1 H-substituted carbothioamide pyrazole derivatives was increased when added to thiazole with different electron-withdrawing groups.

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Cite This Study

El-kasabi et al. (2025) studied this question.

synapsesocial.com/papers/692519b4c0ce034ddc354491 https://doi.org/10.1080/17568919.2025.2575750

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Design, synthesis, in silico studies, molecular docking, ADMET and anticancer activity of novel N -substituted-4-pyrazole derivatives

Key Points

Implication

Abstract

Discussion

Cite This Study

Design, synthesis, in silico studies, molecular docking, ADMET and anticancer activity of novel N -substituted-4-pyrazole derivatives

Key Points

Implication

Abstract

Discussion

Cite This Study

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