Validation and refinement of the 8th edition of the AJCC staging system for esophageal squamous cell carcinoma treated with definitive IMRT or chemo-IMRT: a Chinese multi-institutional retrospective study

Yuanji Xu; Jiao Li; Xin Wang; Lina Zhao; Kuaile Zhao; Wen-Bin Shen; Wencheng Zhang; Honglei Luo; Qifeng Wang; Jie Li; Yun Chen; Jingyuan Wen; Zhunhao Zheng; Yaqi Song; Jianchao Lu; Yu Lin; Fei Zheng; Wenji Xue; Mingqiu Chen; Long-Qi Chen; Zefen Xiao; Jun-qiang Chen

doi:10.1186/s13014-025-02758-w

Key Points

This research aims to validate and enhance the AJCC staging system for esophageal squamous cell carcinoma (ESCC).
Conducted a multi-institutional retrospective study in China.
Evaluated the effectiveness of T4a/T4b subclassification and autoRPA staging.
Analyzed data from patients treated with definitive IMRT or chemo-IMRT.
Combined T4a/T4b and SLN subclassification improved prognostic precision.
AutoRPA staging outperformed the AJCC staging in terms of hazard consistency and predictive accuracy.

Implication

Multi-institutional study shows improved prognostic precision with new staging system in esophageal squamous cell carcinoma.

Abstract

Combining T4a/T4b and SLN subclassification enhanced prognostic precision in ESCC, with the autoRPA staging demonstrating superior hazard consistency, sample balance, and predictive accuracy compared to the 8th edition AJCC staging, thereby guiding therapeutic strategies.

Discussion

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Cite This Study

Xu et al. (2025) studied this question.

synapsesocial.com/papers/692523b2c0ce034ddc3546b8 https://doi.org/10.1186/s13014-025-02758-w

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Validation and refinement of the 8th edition of the AJCC staging system for esophageal squamous cell carcinoma treated with definitive IMRT or chemo-IMRT: a Chinese multi-institutional retrospective study

Key Points

Implication

Abstract

Discussion

Cite This Study

Validation and refinement of the 8th edition of the AJCC staging system for esophageal squamous cell carcinoma treated with definitive IMRT or chemo-IMRT: a Chinese multi-institutional retrospective study

Key Points

Implication

Abstract

Discussion

Cite This Study

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