Case report reveals novel synchronous renal cell carcinoma pathology in a 67-year-old male, suggesting complex malignancy interactions.
Renal cell carcinomas account for 2–3 % of all malignancies. In non-familial syndrome patients, another kidney tumor synchronous, antecedent, or subsequent to diagnosis of RCC is relatively rare. It is very rare for the kidney tumor to be malignant and of differing pathology altogether. We herein describe a 67-year old male with bilateral synchronous masses treated with open bilateral adrenal sparing radical nephrectomy. His final pathology was interestingly found to have novel, differing aggressive cancers: a TFE3-rearranged RCC and a grade 4 WHO clear cell RCC.
No takes yet. Share an insight, caveat, or question.
Shanholtzer et al. (2025) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: