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November 13, 2025International Journal of SurgeryOpen Access

Safety and efficacy of microwave versus laser ablation in the treatment of varicose veins of lower extremities (MOST Trial): a multicenter, open-label, non-inferiority, randomized controlled trial

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Authors

RZRongrong ZhuYLYounan LiLZLei Zhang

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Overview

Randomized controlled trial shows microwave ablation is non-inferior to laser ablation for varicose veins, suggesting comparable outcomes.

Key Points

  • To evaluate the non-inferiority of microwave ablation compared to laser ablation for treating great saphenous vein insufficiency.
  • Multicenter, open-label, non-inferiority, randomized controlled trial
  • 180 patients with great saphenous vein reflux randomized 1:1 to either microwave or laser ablation
  • Primary outcome was GSV occlusion rate at 6 months postoperatively.
  • Microwave ablation demonstrated non-inferiority to laser ablation at 6 months with occlusion rates of 94.32% vs 90.00%
  • Significant improvements in VCSS and AVVQ scores for both interventions over 12 months
  • No significant difference in GSV recanalization time between groups during follow-up.

Cite This Study

Zhu et al. (2025) studied this question.

synapsesocial.com/papers/692523b2c0ce034ddc3547f7https://doi.org/10.1097/js9.0000000000003941
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