What type of study is this?

This is a Meta-Analysis study (also classified as: Systematic Review).

What question did this study set out to answer?

This review evaluates recent advancements and challenges in pharmacological management of menopause.

November 13, 2025Frontiers in Reproductive HealthOpen Access

Precision pharmacology in menopause: advances, challenges, and future innovations for personalized management

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Authors

ZGZhi‐qing Guo

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Implication

Review highlights hormonal and non-hormonal treatments for vasomotor symptoms in menopause, suggesting precision approaches may improve quality of life.

Key Points

This review evaluates recent advancements and challenges in pharmacological management of menopause.
Systematic literature search conducted via PubMed, Cochrane Library, and Web of Science from 2015 to 2025.
Keywords included menopause pharmacological therapy, hormone therapy risks, and non-hormonal VMS treatments.
Two independent reviewers screened abstracts and full texts from RCTs and meta-analyses.
Hormonal therapies effectively reduce vasomotor symptoms by 70%-90% and help maintain bone density.
Non-hormonal options like SSRIs/SNRIs and NK3R antagonists provide reductions in symptoms for patients with contraindications.
Future directions highlight the need for biomarker-guided personalization and AI-driven discovery to improve treatment outcomes.

Cite This Study

Zhi‐qing Guo (2025) studied this question.

synapsesocial.com/papers/692523b2c0ce034ddc3547fd https://doi.org/10.3389/frph.2025.1694240

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Implication

Review highlights hormonal and non-hormonal treatments for vasomotor symptoms in menopause, suggesting precision approaches may improve quality of life.

Precision pharmacology in menopause: advances, challenges, and future innovations for personalized management

Discussion

Member takes

Implication

Key Points

Cite This Study

Precision pharmacology in menopause: advances, challenges, and future innovations for personalized management

Discussion

Member takes

Implication

Key Points

Cite This Study

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