High Biocompatible Janus Adhesive Bioelectronics Patch Enables Reliable and Stable Pathological Cardiac Electrophysiological Mapping

Achieving cardiac electrophysiological labeling with high stability, high fidelity and high resolution still faces significant challenges. Current electrophysiological monitoring is limited by the interference of complex pathologic microenvironments or electromechanical uncoupling of the wet beating heart, making it difficult to ensure the stability and fidelity of signal acquisition. Thus, a highly biocompatible stretchable bioelectronic patch based on asymmetric Janus interface properties is presented, which can realize accurate and stable real‐time in vivo electrophysiological signal acquisition. This Janus adhesive bioelectronic patch significantly reduces mechanical mismatch at the tissue‐device interface, which allows for a highly conformal and tight interfacial coupling with dynamically beating cardiac tissue. This Janus interface design not only effectively inhibits the inflammatory response but also significantly reduces the risk of thoracic adhesion, thus dramatically improving the reliability and accuracy of signal acquisition. Experiments performed in two different Sprague‐Dawley rat models of left ventricular myocardial infarction and right ventricular hypertrophy demonstrated that the Janus bioelectronic patch is able to precisely localize the spatial and temporal characteristics of lesion occurrence, enabling accurate monitoring of the pathological process. Moreover, the patch exhibits excellent mechanical‐electrical stability throughout the cardiac cycle and achieves long‐term, reliable electrophysiological signal acquisition by maintaining continuous and stable interfacial contact with myocardial tissue.