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November 13, 2025APL BioengineeringOpen Access

Heparan sulfate as a central modulator of growth factor dynamics in tissue regeneration

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Authors

KTKeyu TaoASAli ShokoohmandSCSimon M. Cool

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Overview

This perspective reveals how heparan sulfate enhances growth factor activity in tissue regeneration, suggesting its potential in biomaterials.

Key Points

  • To summarize the role of heparan sulfate in modulating growth factor dynamics during tissue regeneration.
  • Review of existing literature on heparan sulfate and growth factors.
  • Discussion on the interactions of heparan sulfate with growth factors.
  • Exploration of heparan sulfate's protective functions and roles in tissue repair.
  • Heparan sulfate enhances the bioactivity of growth factors.
  • Heparan sulfate facilitates the complexation of growth factors with their receptors.
  • Heparan sulfate promotes extracellular matrix remodeling during tissue repair.

Cite This Study

Tao et al. (2025) studied this question.

synapsesocial.com/papers/692523c1c0ce034ddc354c39https://doi.org/10.1063/5.0289409
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