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November 14, 2025BiomoleculesOpen Access

Heparan Sulfate Proteoglycans (HSPGs) and Their Degradation in Health and Disease

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Authors

NGNicola GrecoVMValentina MasolaMOMaurizio Onisto

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Overview

This review reveals the role of heparan sulfate proteoglycans in tissue homeostasis, cancer progression, and therapeutic strategies for immune evasion and fibrosis.

Key Points

  • To provide an overview of heparan sulfate proteoglycans (HSPGs) and their role in health and disease.
  • Reviewed existing literature on HSPG biosynthesis, structure, and functional roles.
  • Analyzed the activity of heparanase (HPSE) in tissue remodeling and disease pathogenesis.
  • Summarized therapeutic strategies targeting HPSE.
  • HSPGs play critical roles in cell adhesion, migration, and signaling of various molecules.
  • HPSE is central in ECM degradation and impacts cancer progression and immune evasion.
  • Dysregulated HPSE activity is linked to conditions like fibrosis and chronic inflammation.

Cite This Study

Greco et al. (2025) studied this question.

synapsesocial.com/papers/692519acc0ce034ddc3541f0https://doi.org/10.3390/biom15111597
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Molecular properties and involvement of heparanase in cancer metastasis and angiogenesis2001 · 602 citations
  2. 2The Pathophysiological Functions of Heparanases: From Evolution, Structural and Tissue‐Specific Perspectives2025 · 7 citations
  3. 3Classification and Molecular Functions of Heparan Sulfate Proteoglycans and Their Molecular Mechanisms with the Receptor2024 · 14 citations
  4. 4Heparan Sulfate Proteoglycans in Immunity2026 · 1 citations
  5. 5Heparan Sulfate Proteoglycans: Master Regulators of Cellular Signaling, Tissue Development, and Neural Function2026