Comparison of Clinical Features and Hemodynamics of Single Ventricle Patients With and Without Interventional Closure of Veno-Venous or Aortopulmonary Collaterals

In single ventricle (SV) patients, veno-venous (VVCs) and major aortopulmonary collaterals (APCs) are common. We aim to determine the differences between patients with and without interventional closure of VVCs or APCs in this single-center, retrospective analysis of 135 SV patients (2006–2021). Anatomical, surgical and clinical features, hemodynamics and PA dimensions were compared. VVC closure was performed in 34 (25%) patients. VVC closure was associated with comprehensive stage I + II (p = 0.05), left PA patch procedure (p = 0.04), Fontan fenestration (p < 0.001), PA pressure >/= 16 mmHg pre-BCPC (p = 0.04) and >/= 15 mmHg pre-TCPC (p = 0.021), lower saturation pre-TCPC (p = 0.04) and smaller PAs (Nakata p = 0.03, total lower lobe index p = 0.001). Patients with VVC closure had a longer hospitalization post-BCPC (p = 0.008) and post-TCPC (p = 0.04) and longer ICU time post-BCPC (p = 0.04). APC closure was performed in 53 (39%) patients. Male sex (p = 0.001), Norwood I procedure (p = 0.04), younger age at BCPC (p = 0.02), higher end-diastolic pressure pre-TCPC (p = 0.04), lower oxygen levels pre-BCPC (p < 0.001) and smaller PAs (Nakata p = 0.08; McGoon p < 0.001) were related to APC closure. Patients with APC closure had a longer hospital (p < 0.001) and ICU (p = 0.005) stay post-TCPC. Significant VVC and APCs are linked to poorer PA growth, worse hemodynamics, lower sats and prolonged hospital/ICU stays, highlighting the need for targeted attention.