The study demonstrates cascade radical cyclization to synthesize phenanthridines under visible-light photoredox catalysis, indicating new pathways for organic synthesis.
An efficient access to 6‐( γ ‐ketoalkylsulfonyl)methyl phenanthridines and 6‐(arylsulfonyl)methyl phenanthridines has been demonstrated under visible‐light photoredox‐catalyzed conditions. Exposure of biphenyl vinyl azides to strained 3°‐cyclopropanols in the presence of Ru(bpy) 3 Cl 2 and SO 2 surrogate DABSO under blue‐LED irradiation triggers a cascade radical cyclization to provide entry to the γ ‐ketosulfones–tethered phenanthridines in moderate to good yields. On the other hand, entry to the 6‐(arylsulfonyl)methyl phenanthridines is demonstrated via a complementary cascade radical cyclization event involving biphenyl vinyl azides and thianthrenium salts in the presence of Na 2 S 2 O 5 and fac ‐Ir(ppy) 3 catalyst under blue‐LED irradiation. The efficiency of the developed reactions has been established through broad substrate‐scope studies, and the mechanistic proposal is backed by incisive mechanistic probing studies.
No takes yet. Share an insight, caveat, or question.
Sahu et al. (2025) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: