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November 13, 2025Bone Marrow TransplantationOpen Access

Current therapeutics for sclerotic and fibrotic manifestations of chronic graft-versus-host disease

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Authors

HCHannah ChoeZDZachariah DeFilipp

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Overview

Current therapeutics improve efficacy and safety for fibrosis in graft-versus-host disease, suggesting new treatment avenues.

Key Points

  • To explore current therapeutic options for managing fibrosis and sclerotic manifestations in chronic graft-versus-host disease (cGVHD).
  • Review current treatment options for cGVHD
  • Evaluate efficacy and safety of therapies for sclerotic and fibrotic complications
  • Discuss methods of assessing treatment effectiveness
  • Treatment options for cGVHD are broadly approved but data on efficacy for fibrosis are limited
  • Recent trials are evaluating safety and efficacy specifically for lung and sclerotic cGVHD
  • Current assessment methods for clinical response are subjective and vary significantly.

Cite This Study

Choe et al. (2025) studied this question.

synapsesocial.com/papers/692523c6c0ce034ddc354f2bhttps://doi.org/10.1038/s41409-025-02743-7
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