What question did this study set out to answer?

The study aims to understand the role of SF3B6 in breast cancer and its molecular mechanisms.

November 13, 2025Scientific ReportsOpen Access

SF3B6 promotes the oncogenic phenotypes of MDA-MB-231 cells by extensively interacting with and regulating transcripts expression and alternative splicing

View Full Paper

Ask AI

Bookmark

Authors

Investigation reveals SF3B6 influences cellular proliferation and apoptosis in breast cancer, indicating its role in tumor progression.

The study aims to understand the role of SF3B6 in breast cancer and its molecular mechanisms.
Transfected siRNA targeting SF3B6 into MDA-MB-231 cells.
Used RNA-seq and iRIP-seq technologies for analysis.
Assessed changes in cellular proliferation, migration, and apoptosis levels.
SF3B6 silencing reduced cellular proliferation and migration.
Increased apoptosis levels were noted in MDA-MB-231 cells.
Widespread changes in differentially expressed genes and regulatory alternative splicing were identified.

Yuan et al. (2025) studied this question.

View Full Paper

Ask AI

Bookmark