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November 13, 2025Current Issues in Molecular BiologyOpen Access

Study on the Protective Mechanism of Dihydromyricetin Against Aflatoxin B1-Induced Injury in Madin–Darby Canine Kidney Cells

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Authors

HZHe ZhaiLXLiuwei XieBLBaoan Li

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Overview

Experimental study reveals Dihydromyricetin protects kidney cells from Aflatoxin B1 damage by reducing inflammation and oxidative stress.

Key Points

  • To investigate how Dihydromyricetin mitigates Aflatoxin B1-induced injury in Madin–Darby canine kidney cells.
  • Four experimental groups were established: control, AFB1 only, and two DMY treatment groups with different concentrations.
  • MDCK cell viability was assessed with various AFB1 and DMY concentrations.
  • Oxidative stress and inflammatory markers were measured after treatments.
  • AFB1 significantly reduced MDCK cell viability (p < 0.01).
  • DMY improved cell viability and reversed oxidative stress markers (p < 0.01).
  • DMY increased superoxide dismutase levels and decreased malondialdehyde and TNF-α (p < 0.01).

Cite This Study

Zhai et al. (2025) studied this question.

synapsesocial.com/papers/692523c6c0ce034ddc354febhttps://doi.org/10.3390/cimb47110947
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Dihydromyricetin preserves β-cell function in type 1 diabetes via PI3K/AKT-mediated metabolic reprogramming2025 · 2 citations
  2. 2Myricetin protects against doxorubicin-induced acute kidney injury in rats by mitigating oxidative damage and apoptotic response2025 · 12 citations
  3. 3Modulatory Effect of Dihydromyricetin on Chronic Alcoholic Liver Injury Based on the FXR-NLRP3 Signaling Pathway and Serum and Liver Metabolomics2024
  4. 4Myricetin protects against doxorubicin-induced liver damage by modulating oxidative and inflammatory pathways2026
  5. 5Protective Effect of Dimethyl Fumarate on Doxorubicin-induced Genotoxicity in Rats2023