A study on the association between serum antiphospholipase A2 receptor antibodies and the hypercoagulable state in Chinese patients with primary membranous nephropathy

Among the participants, 58.5% were anti-PLA2R-positive. All five thrombotic events (9.4% of cohort) occurred in seropositive patients, though this was not statistically significant (16.1% vs. 0%, p = 0.13). TEG profiles indicated hypercoagulability in anti-PLA2R-positive patients, showing significantly shorter R and K times, higher MA, greater CI, larger angle, and elevated LY30 (all p < 0.05). Anti-PLA2R-positive PMN patients demonstrate a hypercoagulable state on TEG compared to seronegative patients. Thrombotic events were only observed in the seropositive group, but the small event number precludes definitive conclusions. These results suggest a link between anti-PLA2R antibodies and coagulation abnormalities, warranting further large-scale prospective studies.