Synapse
⌘+K
Synapse
PulseExploreJournal ClubResearchersJournals
Instagram
HomeJournal ClubExplore
November 12, 2025BMC RheumatologyOpen Access

CMV infection in active systemic lupus erythematosus: clinical characteristics, prognosis and treatment outcomes

View Full Paper
Ask AI
Bookmark
Share

Authors

KSKittiwan SumethkulTKTassanee KitumnuaypongPBPannipa Bupparenoo

Discussion

Loading...

Member takes

Overview

Observational study shows CMV infection impacts mortality in systemic lupus erythematosus, suggesting need for close monitoring and antiviral therapy.

Key Points

  • To identify clinical characteristics and treatment outcomes of Cytomegalovirus infection in patients with systemic lupus erythematosus.
  • Identified SLE patients treated with glucocorticoids and immunosuppressive drugs with active disease.
  • Enrolled patients suspected of CMV infection and tested for CMV PCR.
  • Collected clinical and laboratory characteristics, and SLE disease activity using SLEDAI-2 K.
  • 37 out of 103 SLE patients had CMV infection (35.9%).
  • Among 9 non-surviving patients, 8 (88.9%) had CMV infection, indicating significant mortality.
  • CMV disease was associated with a 66% mortality rate despite ganciclovir treatment.

Cite This Study

Sumethkul et al. (2025) studied this question.

synapsesocial.com/papers/692523d4c0ce034ddc35547bhttps://doi.org/10.1186/s41927-025-00592-x
View Full Paper
Ask AI
Bookmark
Share