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November 12, 2025Frontiers in ChemistryOpen Access

Multi-targeted pharmacological actions and nanodelivery strategies of Garcinia cambogia: from molecular mechanisms to disease treatment

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Authors

HZHang ZhangYCYu-Rou CaoXCXubin Chen

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Overview

Review uncovers therapeutic efficacy and signaling pathways of Garcinia cambogia in cancer and inflammation, suggesting novel delivery methods.

Key Points

  • This review analyzes the pharmacological actions of Garcinia cambogia, focusing on Gambogic Acid and its mechanisms.
  • Systematic analysis of GA's pharmacological profile across signaling pathways.
  • Evaluation of therapeutic efficacy in cancer and inflammatory diseases.
  • Discussion on nanodelivery strategies to improve pharmacokinetics.
  • Garcinia cambogia shows diverse biological activities with significant therapeutic potential.
  • GA regulates multiple signaling pathways and mechanisms of action, including epigenetic reprogramming.
  • Therapeutic efficacy is noted in cancer and inflammatory diseases, but challenges in translation remain.

Cite This Study

Zhang et al. (2025) studied this question.

synapsesocial.com/papers/692523d4c0ce034ddc3555ffhttps://doi.org/10.3389/fchem.2025.1692386
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Also Consider

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  1. 1GARCINIA CAMBOGIA (GARCINIA GUMMI-GUTTA): PHYTOCHEMISTRY, PHARMACOLOGICAL ACTIVITIES AND THERAPEUTIC POTENTIAL – A COMPREHENSIVE REVIEW2026
  2. 2Unveiling the Therapeutic Potential of Gallic Acid: Mechanistic Insights into the Management of Pathogenesis: A Narrative Review2026 · 9 citations
  3. 3[Research progress in pharmacological activities and pharmacokinetics of geniposidic acid].2025
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  5. 5Investigation of the General Molecular Mechanisms of Gallic Acid via Analyses of Its Transcriptome Profile2024 · 1 citations