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November 12, 2025Melanoma Research

Breaking barriers: epithelial–mesenchymal transition role in melanoma invasion and resistance

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Authors

MCMan CaiLWLiang-Yu WangWYWei Yang

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Overview

Review demonstrates epithelial–mesenchymal transition’s role in melanoma invasion and resistance, suggesting new therapeutic strategies.

Key Points

  • This review aims to examine the role of epithelial-mesenchymal transition in melanoma progression and resistance.
  • Detailed review of molecular mechanisms involved in melanoma invasion and therapy resistance.
  • Analysis of transcription factors, signaling pathways, and epigenetic regulators related to EMT.
  • Discussion of biomarkers and therapeutic strategies targeting EMT.
  • Epithelial-mesenchymal transition facilitates melanoma cell invasion and metastasis.
  • Identified key transcription factors include ZEB1, Snail, and Twist.
  • EMT drives resistance to targeted therapies and immunotherapies via tumor microenvironment remodeling.

Cite This Study

Cai et al. (2025) studied this question.

synapsesocial.com/papers/692523d4c0ce034ddc35565dhttps://doi.org/10.1097/cmr.0000000000001068
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