Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
November 12, 2025Cancer Immunology Research

T-cell Subset Features and Distributions Evolve Across the Colorectal Precancer–Cancer Spectrum

View Full Paper
Ask AI
Bookmark
Share

Authors

YTYasutoshi TakashimaACAndressa Dias CostaNANaohiko Akimoto

Discussion

Loading...

Member takes

Overview

This research reveals T-cell infiltration patterns evolve in colorectal cancer, suggesting implications for immune targeting strategies.

Key Points

  • To investigate differences in T-cell infiltrates across the colorectal neoplastic spectrum from precursors to cancer.
  • Utilized a prospective cohort incident-tumor biobank of 1,825 tumor tissue specimens from CRC and precursors.
  • Employed multispectral immunofluorescence assays to analyze T-cell subsets.
  • Compared T-cell densities between different colorectal neoplastic types, including hyperplastic polyps and adenomas.
  • T-cell infiltration patterns varied across different histopathological types of the colorectal spectrum.
  • CD3+CD4+ cells were more abundant than CD3+CD8+ cells in most precursors.
  • Serrated lesions showed higher densities of intraepithelial CD3+CD8+ cells compared to other lesions and carcinomas.

Cite This Study

Takashima et al. (2025) studied this question.

synapsesocial.com/papers/692523d9c0ce034ddc355831https://doi.org/10.1158/2326-6066.cir-25-0481
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Abstract 6571: Proliferative T cell infiltration is associated with colorectal cancer molecular subtypes and cancer specific survival2026
  2. 2Differences in T-cell densities and neighborhood patterns in human colorectal adenomas and sessile serrated lesions2026
  3. 3The Immunological Landscape of Colorectal Pre-Cancers: A Systematic Review2026
  4. 4Peripheral blood immune cell subsets as non-invasive biomarkers of colorectal cancer stage, laterality, metastasis and survival2026
  5. 5B and T Tumor-Infiltrating Lymphocyte Subtypes According to Subsite: A Colon Cancer Immunophenotyping Map2025