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November 12, 2025Frontiers in ImmunologyOpen Access

Single-cell multi-omics analysis reveals cellular subpopulations associated with relapse in high-risk B-ALL following intensified chemotherapy

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Authors

LLLi LiuLLLi LiuXMXiao-Yan Mao

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Overview

Integrated analysis reveals cellular dynamics and molecular pathways associated with treatment failure in high-risk B-ALL.

Key Points

  • The research aims to identify cellular subpopulations in high-risk B-ALL associated with relapse after intensified chemotherapy.
  • Performed integrated single-cell RNA sequencing and ATAC sequencing on patient blood samples and controls.
  • Applied bioinformatic pipelines to analyze cellular composition and chromatin accessibility.
  • Conducted copy number variation analysis and gene ontology enrichment.
  • Identified significant cellular composition differences between remission and non-remission groups.
  • Notable HSC/MPP and Pro-B cell increases in the non-remission group were observed.
  • Drug-resistant subclusters in HSC/MPP and Pro-B cells characterized by specific gene expression patterns were identified.

Cite This Study

Liu et al. (2025) studied this question.

synapsesocial.com/papers/692523d9c0ce034ddc355886https://doi.org/10.3389/fimmu.2025.1645546
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Multi-omic analysis of early minimal residual disease identifies functional and transcriptomic signatures of treatment resistance in pediatric B-cell acute lymphoblastic leukemia2025
  2. 2Pediatric B-Cell Acute Lymphoblastic Leukemia: Comprehensive Genomic Characterization Including SNP-Array and Analysis of Relapse Risk2026
  3. 3Role of Stem-Like Cells in Chemotherapy Resistance and Relapse in pediatric T Cell Acute Lymphoblastic Leukemia2024
  4. 4Prognostic Value and Immune Characterization of Genes Associated with Childhood Acute Leukemia applying Single-Cell RNA Sequencing2025
  5. 5Role of stem-like cells in chemotherapy resistance and relapse in pediatric T-cell acute lymphoblastic leukemia2025