Lipid Variability and the Risk of Incident Peripheral Artery Disease

Ying-Chang Tung; Tsung-Han Tsai; Yu Jui Hsieh; Tzyy‐Jer Hsu; Fu-Chih Hsiao; Chia-Pin Lin; Pao-Hsien Chu

doi:10.1253/circj.cj-25-0504

November 12, 2025Circulation JournalOpen Access

Lipid Variability and the Risk of Incident Peripheral Artery Disease

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Key Points

The research aimed to explore the relationship between lipid variability and the risk of developing peripheral artery disease (PAD).
Multi-institutional database analysis
Evaluated visit-to-visit variability in HDL-C
Adjusted for traditional risk factors for atherosclerosis
Considered mean lipid levels and lipid-lowering therapy
Significant association found between HDL-C variability and incident PAD
Association remains after controlling for traditional risk factors
Findings underline the role of lipid management in PAD prevention

Implication

Database analysis shows HDL-C variability raises PAD risk in individuals, suggesting importance of lipid management.

Abstract

In this multi-institutional database analysis, visit-to-visit variability in HDL-C was significantly associated with the risk of incident PAD, independent of traditional risk factors for atherosclerosis, mean lipid levels, and the use of lipid-lowering therapy.

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Cite This Study

Tung et al. (2025) studied this question.

synapsesocial.com/papers/69252e83c0ce034ddc355ace https://doi.org/10.1253/circj.cj-25-0504

View Full Paper

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Lipid Variability and the Risk of Incident Peripheral Artery Disease

Key Points

Implication

Abstract

Discussion

Cite This Study

Lipid Variability and the Risk of Incident Peripheral Artery Disease

Key Points

Implication

Abstract

Discussion

Cite This Study

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