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November 12, 2025Immunology

Selective Reduction of MAIT Cells in Peripheral Blood T Cell Subsets of Primary Sjögren's Syndrome and Their Clinical Significance

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Authors

ZGZhao GuanBYBohao YangHLHanxi Luo

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Overview

This study demonstrates reduced MAIT cells in peripheral blood of primary Sjögren's syndrome patients, indicating their potential as a diagnostic biomarker.

Key Points

  • This research investigates the distribution of MAIT cells in CD3+ T cell subsets among patients with primary Sjögren's syndrome.
  • Analyzed peripheral blood samples from 39 pSS patients and 45 healthy controls.
  • Categorized CD3+ T cells into CD4+CD8−, double-positive, double-negative, and CD8+CD4− subsets using flow cytometry.
  • Assessed MAIT cell counts and correlated them with clinical indices including inflammatory markers.
  • MAIT cells were significantly reduced in pSS patients compared to healthy controls.
  • Absolute counts of MAIT cells were decreased in double-negative and CD8+CD4− subsets.
  • Proportions of MAIT cells correlated negatively with C-reactive protein and erythrocyte sedimentation rate.

Cite This Study

Guan et al. (2025) studied this question.

synapsesocial.com/papers/69252e8bc0ce034ddc355c73https://doi.org/10.1111/imm.70062
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Also Consider

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  2. 2CD55hi MAIT cells with elevated cytokine secretion and activation markers serve as potential diagnostic indicators in Sjögren’s disease2025 · 1 citations
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  5. 5OP0154 TLR2 INCREASING CD8+T CELL CYTOTOXICITY BY ACTIVATING MITOPHAGY IN PRIMARY SJOGREN’S SYNDROME2024