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November 12, 2025FoodsOpen Access

Effect of Simulated Gastrointestinal Digestion on the Phenolic Composition and Bioactivity of Cymbopogon flexuosus Extracts

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Authors

AAAna Alimpić AradskiDMDanijel D. MilinčićMPMirjana B. Pešić

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Overview

Study shows gastrointestinal digestion alters antioxidant activity and enhances antidiabetic effects of cymbopogon flexuosus extracts.

Key Points

  • This research aims to characterize phenolic composition and evaluate bioactivities of cymbopogon flexuosus extracts after digestion.
  • Characterization of leaf extracts using UHPLC-QToF-MS
  • Assessment of antioxidant activity via multiple tests
  • Analysis of enzyme inhibition activity in α-amylase and α-glucosidase
  • Evaluation of cytotoxicity on HCT-116 colon cancer cells and promotion of HaCaT keratinocyte growth
  • Digested extracts had lower total phenolics and flavonoids compared to controls.
  • Cymbopogon flexuosus extracts showed stronger inhibition of α-glucosidase than α-amylase.
  • Control extracts promoted keratinocyte growth and inhibited cancer cell viability.
  • Gastrointestinal digestion decreased antioxidant activity but improved antidiabetic potential.

Cite This Study

Aradski et al. (2025) studied this question.

synapsesocial.com/papers/69252e8bc0ce034ddc355c8ahttps://doi.org/10.3390/foods14223868
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