Review highlights genetic associations of hidradenitis suppurativa with chromosomal abnormalities and autoinflammatory disorders, suggesting implications for understanding pathogenesis.
Hidradenitis suppurativa (HS) is a severe chronic relapsing inflammatory disorder of the hair follicle unit characterized by painful nodules, abscesses, tunnels, and tracts in intertriginous areas. Although pathogenic mechanisms of the HS have not yet been fully elucidated, genetics is a cardinal component of pathogenesis, and it is essential for providing insight into HS molecular mechanisms. We comprehensively review both common and rare associations of HS with chromosomal and genetic conditions, exploring the pathogenetic link between the diseases. Albeit rare, known the association of HS with chromosomal anomalies, monogenic diseases, genodermatosis and autoinflammatory disorders that are frequently characterized by follicular hyperkeratinisation and epidermal hyperproliferation, may assist in elucidating our understanding in pathomechanism and may enhance the research for new genetic factors in HS.
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Molinelli et al. (2025) studied this question.
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