What question did this study set out to answer?

This research aims to compare the MAFLD and MASLD criteria's effectiveness in predicting liver disease progression.

November 12, 2025LiversOpen Access

From “MAFLD” to “MASLD”: Was This Revolution Worth It? A Head-to-Head Comparison of MAFLD and MASLD Criteria in Estimating Liver Disease Progression and Cardiovascular Risk in Real Life

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The study demonstrates similar outcomes in liver disease risk using MAFLD and MASLD criteria, suggesting relevance for SLD management.

This research aims to compare the MAFLD and MASLD criteria's effectiveness in predicting liver disease progression.
Retrospective analysis of 931 SLD patients from a health database over three years.
Patients categorized by Body Mass Index into lean and not-lean groups.
Evaluated outcomes include AF progression, HCC occurrence, and ACEs.
MAFLD criteria show a better prediction of AF progression in L-SLD patients (p = 0.006).
No significant differences in HCC risk estimates between MAFLD and MASLD (p = 0.741).
Diabetes, high-sensitivity C-reactive protein, and insulin resistance factors associated with AF progression.

Dallio et al. (2025) studied this question.

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