The interplay between metabolism and neuroinflammation in epilepsy: mechanisms and therapeutic perspectives

Emerging evidence underscores the critical role of neuroinflammation and metabolism in the pathophysiology of epilepsy. Metabolic dysregulation and neuroinflammation exacerbate each other, creating a vicious cycle. Although this interplay offers novel insights into the mechanisms underlying neurological disorders and potential therapeutic approaches, its role in epilepsy remains unclear. In this study, we review the interplay between metabolism and neuroinflammation, focusing on glucose, glutamate /γ-aminobutyric acid (GABA), tryptophan-kynurenine, adenosine, and lipid metabolism, aiming to contribute to the development of innovative therapeutic strategies for epilepsy. We also discuss the potential anti-neuroinflammatory and antiepileptic effects of metabolic therapies.