Nonclinical investigations of a novel heart-type fatty acid–binding protein ligand, [18F]LUF: three-lot process validation, safety assessment, and radiation dosimetry

Jun Toyohara; Ito Masahiko; Muneyuki Sakata; Tetsuro Tago; Taichi Komoda; Hiroshi YOSHINO

doi:10.1186/s41181-025-00404-0

November 11, 2025EJNMMI Radiopharmacy and ChemistryOpen Access

Nonclinical investigations of a novel heart-type fatty acid–binding protein ligand, [18F]LUF: three-lot process validation, safety assessment, and radiation dosimetry

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Key Points

This research assesses the safety and validation of a novel ligand for PET imaging.
Conducted nonclinical investigations of the ligand [18F]LUF.
Performed three-lot process validation.
Evaluated pharmacological safety at required doses for imaging.
Assessed radiation dosimetry and potential risks of injection.
[18F]LUF shows acceptable pharmacological safety.
Potential injection risks are within acceptable dose limits.

Implication

Nonclinical assessment shows [18F]LUF as a safe ligand for PET imaging, suggesting manageable radiation dosimetry risks.

Abstract

[¹⁸F]LUF shows acceptable pharmacological safety at the dose required for adequate PET imaging. The potential risks associated with [¹⁸F]LUF injection are well within the acceptable dose limits.

Discussion

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Cite This Study

Toyohara et al. (2025) studied this question.

synapsesocial.com/papers/69252e96c0ce034ddc35616b https://doi.org/10.1186/s41181-025-00404-0

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Nonclinical investigations of a novel heart-type fatty acid–binding protein ligand, [18F]LUF: three-lot process validation, safety assessment, and radiation dosimetry

Key Points

Implication

Abstract

Discussion

Cite This Study

Nonclinical investigations of a novel heart-type fatty acid–binding protein ligand, [18F]LUF: three-lot process validation, safety assessment, and radiation dosimetry

Key Points

Implication

Abstract

Discussion

Cite This Study

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