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November 11, 2025Nature Cardiovascular ResearchOpen Access

Single-cell profiling reveals three endothelial-to-hematopoietic transitions with divergent isoform expression landscapes

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Authors

WNWen Hao NeoMFMuhammad Zaki Hidayatullah FadlullahHBHarshangda Bhatnagar

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Overview

Single-cell profiling identifies divergent isoform expression in endothelial populations influencing hematopoietic stem cell fate.

Key Points

  • This research investigates how different endothelial populations influence hematopoietic stem cell development.
  • Combined differentiation assays with single-cell transcriptome data.
  • Analyzed extra-embryonic yolk sac and intra-embryonic aorta–gonad–mesonephros HE populations.
  • Identified three differentiation trajectories within endothelial populations.
  • Three distinct endothelial subsets identified: erythromyeloid, lymphomyeloid, and hematopoietic stem and progenitor cell-primed.
  • AGM HE showed higher isoform complexity and specific expression patterns for stemness-associated factors.
  • Chromatin modifiers and spliceosome components enriched in AGM HE.

Cite This Study

Neo et al. (2025) studied this question.

synapsesocial.com/papers/69252e96c0ce034ddc3561dehttps://doi.org/10.1038/s44161-025-00740-z
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Single-cell atlas of major haematopoietic tissues sheds light on blood cell formation from embryonic endothelium2019
  2. 2Developmental Origins of the Heterogeneous Hematopoiesis2025
  3. 3Fetal-restricted hematopoietic progenitors arise from hemogenic endothelium in vitelline and umbilical arteries2026 · 1 citations
  4. 4Trimodal single-cell profiling reveals principles of cell fate acquisition in human erythropoiesis.2025 · 1 citations
  5. 5Identification of a mesodermal progenitor for the pro-definitive angio-hematopoietic lineage2024 · 2 citations