What type of study is this?

This is a Human Clinical Trial study (also classified as: RCT).

What question did this study set out to answer?

This research aims to compare the efficacy and safety of low-dose intravenous indomethacin against conventional doses for PDA closure in preterm neonates.

November 11, 2025Scientific ReportsOpen Access

The efficiency and safety of low-dose intravenous indomethacin for closure of patent ductus arteriosus in preterm neonate: a randomized controlled trial

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Authors

WHWasana Hongkan NPNarueporn PetarwutChonburi Hospital TSThanatda SiripornChonburi Hospital

Discussion

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Implication

Randomized controlled trial shows similar efficacy and safety of low-dose indomethacin for closure of patent ductus arteriosus in preterm neonates, indicating non-inferiority compared to conventional.

Key Points

This research aims to compare the efficacy and safety of low-dose intravenous indomethacin against conventional doses for PDA closure in preterm neonates.
Conducted a randomized controlled, non-inferiority trial
Included preterm neonates <34 weeks or body weight <1,500 g
Subjects randomized to receive either 2 or 3 doses of indomethacin
Evaluated various clinical outcomes and incidence of complications over 72 hours and 7 days
No significant difference in PDA closure success rates within 72 hours and 7 days
Incidence rates of re-medication, surgery, necrotizing enterocolitis, and acute kidney injury did not differ between groups
Low-dose indomethacin showed similar safety and efficacy to conventional treatment in the studied population

Cite This Study

Hongkan et al. (2025) studied this question.

synapsesocial.com/papers/69252e96c0ce034ddc35627d https://doi.org/10.1038/s41598-025-23285-4

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The efficiency and safety of low-dose intravenous indomethacin for closure of patent ductus arteriosus in preterm neonate: a randomized controlled trial

Discussion

Member takes

Implication

Key Points

Cite This Study

The efficiency and safety of low-dose intravenous indomethacin for closure of patent ductus arteriosus in preterm neonate: a randomized controlled trial

Discussion

Member takes

Implication

Key Points

Cite This Study

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