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November 11, 2025Investigative RadiologyOpen Access

Quantitative Analysis of Gadolinium Deposits in Liver Tissue of Patients After Single or Multiple Gadolinium-based Contrast Agent Application

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Authors

CBChristian BayerlMSMehrgan ShahryariRRRolf Reiter

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Overview

Analysis shows a relationship between gadolinium retention and number of applications in liver tissue, indicating potential deposition following MRI contrast use.

Key Points

  • Gadolinium was detected in all liver samples, with mass fractions showing considerable range across specimens.
  • The median retention of gadolinium was 0.348 µg/g, with strong negative correlation to time since last GBCA administration.
  • Using inductively coupled plasma–mass spectrometry, samples from 25 subjects were analyzed for gadolinium mass fractions and histopathologic features.
  • Findings highlight potential concerns about gadolinium retention in liver tissue, particularly after multiple contrast agent administrations.

Cite This Study

Bayerl et al. (2025) studied this question.

synapsesocial.com/papers/69252e96c0ce034ddc356347https://doi.org/10.1097/rli.0000000000001254
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Gadolinium deposition in the liver and brain in a rat model with liver fibrosis after intravenous administration of gadoxetate disodium2024 · 4 citations
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  3. 3Safety of a Tailored Gadolinium-Based Contrast Agent Protocol Considering Excretion Pathways in Patients with Renal Impairment2026
  4. 4Cerebral Accumulation of Gadolinium (Gd3+) and Related Cellular Stress Pathways in Rat Brain Tissue2026
  5. 5Comprehensive Magnetic Resonance Imaging Relaxometry of Gadolinium‐Based Contrast Agents: A Systematic Study of Transmetallation and Transchelation Processes With Zinc Ions and Heparin2026