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The review discusses the roles of autophagy and cellular senescence in glioblastoma and their implications for aging and treatment.

November 11, 2025CellsOpen Access

Role of the Interplay Between Autophagy and Cell Senescence in the Pathogenesis and Therapeutics of Glioblastoma in the Aging Population

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Review reveals autophagy and tumor suppressor pathways influence glioblastoma outcomes in aging, highlighting new therapeutic targets.

The review discusses the roles of autophagy and cellular senescence in glioblastoma and their implications for aging and treatment.
Review of relevant literature on glioblastoma pathogenesis and therapies
Analysis of aging-associated molecular signaling mechanisms
Exploration of intracellular signaling transduction related to autophagy and senescence
Identified interactions between autophagy and cellular senescence influence GBM development
Highlighted importance of tumor suppressor pathways in GBM pathology
Suggested potential therapeutic targets to improve patient outcomes

Eliezer Masliah (2025) studied this question.

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