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November 11, 2025Neurology and TherapyOpen Access

Time-Dependent Effect of Anti-seizure Medications on Bone Metabolism in Patients with Epilepsy: A Cross-Sectional Study

Bo-Fei Chen Jiahui Guo Zhiruo Qiu Beibei Shen Yi Shi Huali Luo Lina Jiang Yi Wang Lei Chen Ping Su Xiuying Chen Jia-Jia Fang

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Key Points

This research aims to evaluate how anti-seizure medications affect bone metabolism in patients with epilepsy.
Cross-sectional study design
Assessment of bone metabolic markers
Focus on patients undergoing long-term anti-seizure medication therapy
Findings indicate osteoclast inhibition occurs prior to osteoblast dysfunction after prolonged ASM use.
Reduction in bone formation markers suggests impaired osteoblastic function.
The β-CTX/OC ratio is identified as an early biomarker for monitoring bone health deterioration.

Implication

Cross-sectional study reveals changes in bone biomarkers in epilepsy patients, suggesting the need for monitoring bone health.

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Cite This Study

Chen et al. (2025) studied this question.

synapsesocial.com/papers/69252e9ec0ce034ddc356653 https://doi.org/10.1007/s40120-025-00853-4

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Antiseizure Medications and Bone Health2025 · 11 citations
2Evaluation of Osteoporosis Among Epileptic Patients on Monotherapy2024 · 2 citations
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4Antiseizure Medication Withdrawal, Risk of Epilepsy, and Longterm EEG Trends in Acute Symptomatic Seizures or Epileptic EEG Patterns2024 · 9 citations
5Comprehensive insights into bone health, hormonal patterns, and fracture risks among men with drug resistant epilepsy: a crucial evaluation.Case-Control Study · 2026