Experimental evidence shows spreading depolarization can trigger seizure-like activity in the hippocampus, suggesting implications for migraine-aura seizures.
This is the first experimental evidence that SD can trigger seizure-like activity in particular regions of awake non-epileptic brain. We suggest that the phenomenon may be relevant to mechanisms of migraine-aura triggered seizures (migralepsy).
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Smirnova et al. (2025) studied this question.
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