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November 11, 2025Cancer Research

Response to Immune Checkpoint Blockade is Enhanced in the Presence of Hematopoietic TET2 Inactivation

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Authors

VRVincent RondeauSBSuraj BansalMBMarco M. Buttigieg

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Overview

Research demonstrates improved ICB response in melanoma and colorectal cancer due to TET2 inactivation, suggesting a biomarker for therapy.

Key Points

  • To investigate the impact of hematopoietic TET2 inactivation on immune checkpoint blockade response in cancer.
  • Used mouse models with hematopoietic Tet2 mutations
  • Analyzed immune cell involvement including phagocytes and T cells
  • Compared immune responses in TET2-mutant and wild-type models
  • Hematopoietic TET2 inactivation enhanced ICB response
  • TET2 inactivation linked to increased immune cell activation and infiltration in tumors
  • Melanoma patients with TET2-CH had 6-fold greater odds of benefiting from ICB therapy

Cite This Study

Rondeau et al. (2025) studied this question.

synapsesocial.com/papers/69252ea3c0ce034ddc3566e4https://doi.org/10.1158/0008-5472.can-24-3329
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Hematopoietic Tet2 inactivation enhances the response to checkpoint blockade immunotherapy2024 · 2 citations
  2. 2When Coconspirators Avert the Crime: Clonal Hematopoiesis Driven by <i>TET2</i> Loss Improves Response to Cancer Immunotherapy2026
  3. 3Human TET2-mutant clonal hematopoiesis expansion is driven by distinct inflammatory signaling responses in stem cells versus myeloid progeny.2025 · 8 citations
  4. 4Metabolic control of innate immune activation in TET2-mutant clonal hematopoiesis2026 · 2 citations
  5. 5Single-cell multiomic profiling of gene mutation, chromatin accessibility, and gene expression in TET2-mutant clonal hematopoiesis2025