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This review examines the contamination and toxicity of deoxynivalenol (DON) in food and feed.

November 11, 2025ToxinsOpen Access

Deoxynivalenol and Its Metabolites: Contamination, Metabolism, and Toxicity

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Review outlines contamination and toxicity of deoxynivalenol in livestock, suggesting genetic regulation may mitigate risks.

This review examines the contamination and toxicity of deoxynivalenol (DON) in food and feed.
Overview of DON contamination and its transmission through the food chain.
Analysis of metabolic pathways in animals and toxic effects of DON and its metabolites.
Integration of regulatory thresholds and mitigation strategies related to DON.
Identified various toxic effects of DON including cytotoxicity, immunotoxicity, neurotoxicity, and hepatotoxicity.
Highlighted the urgent need for effective biodegradation technologies and genetic regulation to manage DON contamination.

Lin et al. (2025) studied this question.

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