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November 11, 2025Folia MicrobiologicaOpen Access

Marine-derived Aspergillus sp.-mediated biosynthesis of silver nanoparticles with antioxidant activity and immunomodulatory apoptosis induction in melanoma cells

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Authors

MHMervat G. HassanSYSomaya Sh. YoussefMAMohamed A. Abdelmonem

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Overview

Biosynthesis of silver nanoparticles demonstrates immunomodulatory effects in melanoma cells, suggesting potential in cancer therapy.

Key Points

  • Biosynthesized silver nanoparticles exhibit significant antioxidant activity against free radicals, enhancing therapeutic potential.
  • Characterization revealed nanoparticles' average size of 45.16 nm, with notable biosynthesis evidence from the fungal isolate.
  • Immunomodulatory effects were marked by apoptosis induction and elevated IL-1β in Sk-Mel-28 melanoma cells, promoting apoptosis.
  • The findings propose biogenic silver nanoparticles could greatly benefit nanomedicine and cancer therapies in future studies.

Cite This Study

Hassan et al. (2025) studied this question.

synapsesocial.com/papers/69252ea3c0ce034ddc356719https://doi.org/10.1007/s12223-025-01370-5
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Characterization Studies and Antimicrobial Efficacy of Silver Nanoparticles Synthesized Using Aspergillus niger: A Biological Driven Approach2024
  2. 2Biosynthesis and Biological Properties of Nano-Silver from Aspergillus terreus Towards Antibacterial and Antitumor Applications2026 · 1 citations
  3. 3Endophytic Aspergillus hiratsukae mediated biosynthesis of silver nanoparticles and their antimicrobial and photocatalytic activities2024 · 8 citations
  4. 4Multifaceted Applications of Synthesized Silver Nanoparticles From Marine Fungus <i>Aspergillus flavus</i> MK4: Antimicrobial, Anticancer, and Wound‐Healing Properties2025
  5. 5Biosynthesis of silver nanoparticles by endophytic <i>Aspergillus terreus</i> : Biomolecular capping in antioxidant, metal-chelating and genoprotective activities2026