Palladium-catalysed synthesis produces benzazepine derivatives from indolin-2-ones and alkynes, suggesting effective activation methods.
We developed an efficient palladium-catalyzed synthesis of benzazepine derivatives from (E,Z)-3-(arylidene)indolin-2-ones with alkynes, affording the desired products in good yields. The reaction proceeds via a palladium-catalyzed C-H/N-H activation, followed by alkyne insertion and reductive elimination sequences. Furthermore, we have also demonstrated the gram scale reaction as well as some synthetic transformations of the annulated products.Key words Benzazepines, (E,Z)-3-
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Parthasarathy et al. (2025) studied this question.
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