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November 11, 2025Brain CommunicationsOpen Access

Hippocampal and cortical activity reflect early hyperexcitability in an Alzheimer’s mouse model

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Authors

MDMarina DiachenkoGKGeorgii KrivosheinAMArn M. J. M. van den Maagdenberg

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Overview

Findings reveal altered biomarkers and hippocampal activity in Alzheimer’s model mice, indicating early hyperexcitability.

Key Points

  • This research aims to investigate early hyperexcitability in an Alzheimer's mouse model through neural activity analysis.
  • Recorded local field potentials weekly in APP/PS1 and wildtype mice from 3 to 11 months of age.
  • Assessed functional excitation-inhibition ratio and phase-amplitude coupling in neural circuits.
  • Analyzed correlation between excitation-inhibition metrics and spiking activity.
  • APP/PS1 mice showed increased functional excitation-inhibition ratio at 6 months.
  • Elevated population spiking activity was detected in APP/PS1 mice.
  • Significantly altered theta-gamma phase-amplitude coupling was noted in affected brain regions.

Cite This Study

Diachenko et al. (2025) studied this question.

synapsesocial.com/papers/69252ea8c0ce034ddc35698ehttps://doi.org/10.1093/braincomms/fcaf443
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Reduced inhibition, bursting, and accelerated oscillations drive early hippocampal hyperactivity in Alzheimer’s disease in vivo2026
  2. 2Slow-wave–modulated high-frequency oscillations reveal early network abnormalities in pre-pathological 5XFAD mice2026 · 1 citations
  3. 3A Balancing Act: Amyloid-β, Tau, and Excitation–Inhibition in Alzheimer's Disease2026
  4. 4Disruption of electrophysiological rhythms and memory impairment in an Alzheimer’s transgenic rat model2025 · 3 citations
  5. 5Prodromal changes in cortical neuron physiology before amyloid pathology in a mild model of Alzheimer’s disease2026 · 1 citations